Pharmaceutical Nanomaterials for Nucleic Acid Delivery
2021-09-28 14:07:00
Job Responsibilities
1. Read the literature extensively to understand the clinical needs of the disease and the characteristics of existing drugs, including defects;
2. According to the needs of the disease and the defects of existing drugs, design a feasible drug delivery system to obtain better absorption, sustained release, targeting, stability, safety, etc.;
3. Preparation, modification and characterization of drug delivery systems (liposomes, hydrogels, etc.);
4. Evaluate the in vitro and in vivo drug delivery capabilities of the nanoformulations, as well as the in vivo pharmacodynamics;
5. Participate in the operation and maintenance of the nano preparation laboratory, the installation and debugging of research equipment and the maintenance of daily instruments;
6. Responsible for the delivery technology of mRNA and sgRNA, the development of new liposome/lipid nanoparticle (LNP)-based mRNA preparation technology, including the design of delivery carrier compounds (such as lipid compounds), formulation design and screening , Process research, preparation process, quality characterization;
7. Responsible for the research and development of nucleic acid drugs, nano, microsphere liposome/lipid nanoparticle (LNP) delivery technology formulations, including formulation development literature research, program design, formulation formulation screening optimization, formulation process research, stability inspection and Pilot scale up and other work;
8. Participate in the development of new nucleic acid drugs, nanometer and microsphere liposome preparation technologies, including related technologies for delivery of carrier compounds (such as lipid compounds).
Qualifications
1. Obtain a master's degree or above in the fields of organic chemistry, medicinal chemistry, medicinal polymers, and pharmaceutical preparations;
2. Understand the microenvironment of cells and tissues, and have a certain understanding of disease pathology and cell biology;
3. Have relevant research experience in drug delivery, and be familiar with the advantages and disadvantages of different delivery systems and materials;
4. Be good at thinking, love your job, and have a good team spirit.
Resume delivery email: HR@innovecbio.com