Pharmaceutical Nanomaterials for Nucleic Acid Delivery

  • Time of issue:2021年09月28日
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Pharmaceutical Nanomaterials for Nucleic Acid Delivery

  • Time of issue:2021-09-28

Job Responsibilities

1. Read the literature extensively to understand the clinical needs of the disease and the characteristics of existing drugs, including defects;

2. According to the needs of the disease and the defects of existing drugs, design a feasible drug delivery system to obtain better absorption, sustained release, targeting, stability, safety, etc.;

3. Preparation, modification and characterization of drug delivery systems (liposomes, hydrogels, etc.);

4. Evaluate the in vitro and in vivo drug delivery capabilities of the nanoformulations, as well as the in vivo pharmacodynamics;

5. Participate in the operation and maintenance of the nano preparation laboratory, the installation and debugging of research equipment and the maintenance of daily instruments;

6. Responsible for the delivery technology of mRNA and sgRNA, the development of new liposome/lipid nanoparticle (LNP)-based mRNA preparation technology, including the design of delivery carrier compounds (such as lipid compounds), formulation design and screening , Process research, preparation process, quality characterization;

7. Responsible for the research and development of nucleic acid drugs, nano, microsphere liposome/lipid nanoparticle (LNP) delivery technology formulations, including formulation development literature research, program design, formulation formulation screening optimization, formulation process research, stability inspection and Pilot scale up and other work;

8. Participate in the development of new nucleic acid drugs, nanometer and microsphere liposome preparation technologies, including related technologies for delivery of carrier compounds (such as lipid compounds).



1. Obtain a master's degree or above in the fields of organic chemistry, medicinal chemistry, medicinal polymers, and pharmaceutical preparations;

2. Understand the microenvironment of cells and tissues, and have a certain understanding of disease pathology and cell biology;

3. Have relevant research experience in drug delivery, and be familiar with the advantages and disadvantages of different delivery systems and materials;

4. Be good at thinking, love your job, and have a good team spirit.


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