Pharmaceutical Nanomaterials for Nucleic Acid Delivery 2021-09-28 14:07:00
Job Responsibilities 1. Read the literature extensively to understand the clinical needs of the disease and the characteristics of existing drugs, including defects; 2. According to the needs of the disease and the defects of existing drugs, design a feasible drug delivery system to obtain better absorption, sustained release, targeting, stability, safety, etc.; 3. Preparation, modification and characterization of drug delivery systems (liposomes, hydrogels, etc.); 4. Evaluate the in vitro and in vivo drug delivery capabilities of the nanoformulations, as well as the in vivo pharmacodynamics; 5. Participate in the operation and maintenance of the nano preparation laboratory, the installation and debugging of research equipment and the maintenance of daily instruments; 6. Responsible for the delivery technology of mRNA and sgRNA, the development of new liposome/lipid nanoparticle (LNP)-based mRNA preparation technology, including the design of delivery carrier compounds (such as lipid compounds), formulation design and screening , Process research, preparation process, quality characterization; 7. Responsible for the research and development of nucleic acid drugs, nano, microsphere liposome/lipid nanoparticle (LNP) delivery technology formulations, including formulation development literature research, program design, formulation formulation screening optimization, formulation process research, stability inspection and Pilot scale up and other work; 8. Participate in the development of new nucleic acid drugs, nanometer and microsphere liposome preparation technologies, including related technologies for delivery of carrier compounds (such as lipid compounds).   Qualifications 1. Obtain a master's degree or above in the fields of organic chemistry, medicinal chemistry, medicinal polymers, and pharmaceutical preparations; 2. Understand the microenvironment of cells and tissues, and have a certain understanding of disease pathology and cell biology; 3. Have relevant research experience in drug delivery, and be familiar with the advantages and disadvantages of different delivery systems and materials; 4. Be good at thinking, love your job, and have a good team spirit.   Resume delivery email:  
Upstream Process Development Engineer 2021-09-28 14:04:37
Job Responsibilities 1. Development and optimization of upstream processes: including experimental design, operation, data analysis and report writing; 2. Upstream process enlargement, understanding the characteristics of biochemical reactors of different scales, including shake flasks, 2L, 10L, 50L, etc.; 3. Proficiency in using various instruments developed by upstream processes, including different biochemical reactor operations and parameter settings; 4. Skilled operation related characterization experiments, including DLS, SDS-PAGE, TCID50, ddPCR, etc.; 5. Develop relevant upstream processes for different products; 6. Writing experiment reports and standard operating procedures, etc.; 7. Assist in technology transfer and GMP production.   Qualifications 1. A doctorate degree in bioengineering, chemical engineering, or pharmaceutical engineering related majors with relevant scientific research background, or a master's degree in related majors and industrial experience in biopharmaceutical process development, or a bachelor degree with years of upstream process development experience; 2. Familiar with the methods of upstream process development; 3. Familiar with DOE and other process optimization methods and data analysis software; 4. Serious and responsible work, self-motivated and teamwork spirit; 5. Good expression and communication skills; 6. Familiar with office software and good writing skills.   Resume delivery email:  
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